Life Sciences Research

E. Lucile White Publications

L. Rasmussen, C.B. Maddox, B. Harten, E. L. White. A Successful LIMS Implementation: Case Study at Southern Research Institute. J. Assoc. Lab. Automation. In press (2207).

E.L. White, K. Southworth, L. Ross, S. Cooley, R.B. Gill, M.I. Sosa, A. Manouvakhova, L. Rasmussen, C. Goulding, D. Eisenberg, and T.M. Fletcher III. A Novel Inhibitor of Mycobacterium tuberculosis Pantothenate Synthetase. J. Biomol. Screen. 12: 100-105, 2007.

W. E. Severson, N. Shindo, M.I. Sosa, T.M. Fletcher III, E.L. White, S. Ananthan, and C.B. Jonsson. Development and Validation of a High Throughput Screen for Inhibitors of SARS CoV and its Application in Screening a 100,000 Compound Library. J. Biomol. Screen. 12: 33-40, 2007.

J.W. Noah, W. Severson, D.L. Noah, L. Rasmussen, E.L. White, and C.B. Jonsson. A Cell-based Luminescence Assay is Effective for High-throughput Screening of Potential Influenza Antivirals. Antiviral Research 73: 50-9, 2007

R.C. Reynolds, L. Seitz, V. Pathak, W. Barrow, L.J. Ross, E.L. White, and W. Suling. 2,4-Diamino-5-deaza-6-Substituted Pteridines as Antitubercular Agents. J.Med.Chem. 2005.

27. D.W. Borhani and E.L.White. Polymerization of C-terminally Truncated Mycobacterium tuberculosis FtsZ is unlikely to be physiologically relevant. Microbiol. 150: 2903-3906, 2004.

A.K.W. Leung, E.L. White, L.J. Ross, R.C. Reynolds, J.A. DeVito, and D.W. Borhani. Structure of the Mycobacterium tuberculosis FtsZ Reveals Unexpected G Protein-like Conformational Switches. J. Mol. Biol. 342: 953-970, 2004.

R.C. Reynolds, S. Srivastava, L.J. Ross, W.J. Suling, and E.L. White. A New 2-Carbamoyl Pteridine that Inhibits Mycobacterial FtsZ. Bioorg. Med. Chem. Lett. 14: 3161-4, 2004.

E.L. White, L.J. Ross, A. Cunningham, and V .Escuyer. Cloning, Expression, and Characterization of Mycobacterium tuberculosis Dihydrofolate Reductase. FEMS Microbiol. Lett. 232: 101-5, 2004.

E.L. White, W.J. Suiling, L.J. Ross, L.E. Seitz, and R.D. Reynolds. 2-Alkoxycarbonylaminopyridines: Inhibitors of Mycobacterium tuberculosis FtsZ. J. Antimicrob. Chenother. 50: 111-4, 2002.

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R.W. Buckheit, Jr., K. Watson, V. Fliaks-Boltz, J. Russell, T.L. Loftus, M.C. Osterling, J.A. Turpin, L.A. Pallansch, E.L. White, J.W. Lee, S.H. Lee, J.W. Oh, H.S. Kwon, S.G. Chung, and E.H. Cho. SJ-3366, a Unique and Highly Potent Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1) that also Inhibits HIV-2. Antimicrob. Agents Chemother. 45: 393-400, 2001.

E.L. White, L.J. Ross, R.C. Reynolds, L.E. Seitz, G.D. Moore and D.W. Borhani. The Slow Polymerization of Mycobacterium tuberculosis FtsZ. J. Bacteriol. 182: 4028-4034, 2000.

E.L. White, L.J. Ross, R.L. Davis, S.Z. van Ginkel, G. Vasanthakumar, and D.W. Borhani. The Two Toxoplasma gondii Hypoxanthine-Guanine Phosphoribosyltransferase Isozymes form Heterotetramers. J. Biol. Chem. 275: 19218-19223, 2000.

A. Héroux, E.L. White, L.J. Ross, R.L. Davis, A.P. Kuzin, and D.W. Borhani. Substrate Deformation in a Hypoxanthine-Guanine Phosphoribosyltransferase Ternary Complex: The Structural Basis for Catalysis. Structure 8: 1309-1318, 2000.

E.L. White, L.J. Ross, V.E.Steele, G.J. Kelloff, and D.L. Hill. Screening of Cancer Preventing Chemicals as Aromatase Inhibitors In Vitro. Anticancer Res. 19: 1017-1020 1999.

R.W. Buckheit, Jr., C. Lackman-Smith, M.J. Snow, S.M. Halliday, E.L. White, L.J. Ross, V.K. Agrawal, and A.D. Broom. PMTI, a Broadly Active Unusual Single-Stranded Polyribonucleotide, Inhibits HIV Replication by Multiple Mechanisms. Antiviral Chem. Chemother. 5: 23-32, 1999.

E.L. White, W. Chao, L.J. Ross, D.W. Borhani, P.D. Hobbs, U. Velapartha, and M.I. Dawson. Michellamine Alkaloids Inhibit Protein Kinase C. Arch. Biochem. Biophys. 365: 25-30, 1999.

E.L. White, L.J. Ross, P.D. Hobbs, U. Velapartha, and M.I. Dawson. Antioxidant Activity of Michellamine Alkaloids. Anticancer Res. 19: 1033-1035, 1999.

R.W. Buckheit, Jr., E.L. White, V. Fliakas-Boltz, J.Russell, T.L. Stup, T.L. Kinjerski, M.C. Osterling, A. Weigand, and J.P. Bader. Unique Anti-Human Immunodeficiency Virus activity of the Nonnucleoside Reverse Transcriptase Inhibitors Calanolide A, Costatolide A, and Dihydrococostatolide. Antimicrob. Agents Chemother. 43:1827-1834, 1999.

A. Héroux, E.L. White, L.J. Ross, R.L. Davis, and D.W. Borhani. Crystal Structure of Toxoplasma gondii Hypoxanthine-Guanine Phosphoribosyltransferase with XMP, Pyrophosphate, and Two Mg2+ Ions Bound: Insights into the Catalytic Mechanism. Biochemistry 38: 14495-14506, 1999.

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A. Héroux, E.L. White, L.J. Ross, and D.W. Borhani. Crystal Structures of the Toxoplasma gondii Hypoxanthine-Guanine Phosphoribosyltransferase-GMP and -IMP Complexes: Comparison of Purine Binding Interactions with the XMP Complex. Biochemistry 38: 14485-14494, 1999.

E.L. White, L.M. Rose, P.W. Allan, R.W. Buckheit, Jr., W.M. Shannon, and J.A. Secrist III. Polyamine Pools in Human Immunodeficiency Virus Infected Cells. JAIDS 17:101-103, 1998.

E.L. White, B.J. Bowdon, and W.M. Shannon. Safety Factors Involved in the Extraction of Biologically Active Proteins from Human Immunodeficiency Virus. J. Virol. Methods 70:113-115, 1998.

E. L. White, L.J. Ross, S.M. Schmid, G.J. Kelloff, V.E. Steele, and D.L. Hill. Screening of Potential Cancer Preventing Chemicals for Induction of Glutathione in Rat Liver Cells. Oncology Reports 5:507-512, 1998.

E.L. White, L.J. Ross, S.M. Schmid, G.J. Kelloff, V.E. Steele, and D.L. Hill. Screening of Potential Cancer-Preventing Chemicals for Inhibition of Induction of Ornithine Decarboxylase in Epithelial Cells from Rat Trachea. Oncology Reports 5:717-722, 1998.

E.L. White, L. Westbrook, M.G. Hollingshead, and W.M. Shannon. Optimization of the Reverse Transcriptase Assay for the Detection of Viral Burden in Mice Infected with Rauscher Murine Leukemia Virus. J. Virol. 62:63-70, 1996.

R.W. Buckheit, Jr., E.L. White, J. Germany-Decker, L.B. Allen, L.J. Ross, W.M. Shannon, P.A.J. Janssen, and M.A. Chirigos. Cell-based and Biochemical Analysis of the Anti-HIV Activity of Combinations of 3'-Azido-3'-deoxythymidine and Analogues of TIBO. Antiviral Chem. & Chemother. 5:35-42,1994.

E.L. White, G. Arnett, J.A. Secrist III, and W.M. Shannon. Characterization of S-Adenosylmethionine Decarboxylase Induced by Human Cytomegalovirus Infection. Virus Res. 31:255-263, 1994.

E.L. White, W.B. Parker, L.J. Ross, and W.M. Shannon. Lack of Synergy in the Inhibition of HIV-1 Reverse Transcriptase by Combinations of the 5'-Triphosphates of Various Anti-HIV Nucleoside Analogs. Antiviral Res.22:295-308, 1993.

E.L. White, R.W. Buckheit, Jr., L.J. Ross, J.M. Germany, K. Andries, R. Pauwels, P.A.J. Janssen, W.M. Shannon, and Michael A. Chirigos. A TIBO Derivative, R82913, is a Potent Inhibitor of HIV-1 Reverse Transcriptase with Heteropolymer Templates. Antiviral Res. 16:257-267, 1991.

W.B. Parker, E.L. White, S.C. Shaddix, L.J. Ross, R.W. Buckheit, Jr., J.M. Germany, J.A. Secrist III, R. Vince, and W.M. Shannon. Mechanism of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Human DNA Polymerases α, β, γ and by the 5'-Triphosphates of Carbovir, 3'-Azido-3'-Deoxythymidine, 2',3'-Dideoxyguanosine, and 3'-Deoxythymidine. A Novel RNA Template for the Evaluation of Antiretroviral Drugs. J. Biol. Chem. 266:1754-1762, 1991.

E.L. White. A Novel RNA Template for the Study of Reverse Transcriptase Inhibitors and Its Application for Understanding the Nature of the TIBO Binding Site. Wiss. Zeitschrift der Humboldt-Universität zu Berlin R. Medizin 40:44-47, 1991.

Book Chapters

D.L. Noah, E.L. White, and J.W. Noah. Development of High-Throughput Assays for Influenza, in Combating the Threat of Avian Influenza: Drug Discovery Approaches, Paul F. Torrence (ed), Willey and Sons (pub), In press (2007).

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