Southern Research has purchased several libraries from commercial suppliers for use in its HTS program. One example, a 100,000 compound library from ChemBridge Corporation was pre-filtered using a number of drug-likeness parameters including molecular weight <500, <5 hydrogen bond donors, and <10 rotable bonds. Over 28 reactive groups such as carbodiimides, diazonium salts, peroxides, and diazines were also removed, resulting in 100,000 compounds with drug-like properties that meet a number of criteria including the Lipinski rules. Smaller sets of 3,000 and 10,000 compounds have been made that represent the chemical diversity of this library. Access to this library and other similar libraries is available with by contract.
In addition to this commercially purchased library, Southern Research has its own proprietary compound library resulting from over 30 years of in-house medicinal chemistry. This collection of ~20,000 compounds is a unique resource. Various smaller compound collections are also available on-site, including some natural product collections. These libraries are available for selected assays as part of a drug discovery partnership.
High-Throughput Screening
HTS Informatics
HTS Equipment
HTS Publications
HTS Virtual Poster Session
Chemical Repository
