Tomris Mustafa, Maurizio Grimaldi, and Lee E. Eiden. The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for PACAP-evoked neurosecretion. JBC published January 9, 2007 as doi:10.1074/jbc.M609638200 [Abstract] [Accepted Manuscript]
Grimaldi M. Astrocytes refill intracellular Ca2+ stores in the absence of cytoplasmic [Ca2+]i elevation: A functional rather than a structural ability. J Neurosci Res. 84(8):1738-49 (2006).
Zhao W., Weissman D.M., and Grimaldi M. Specific Localization of the annexin II heterotetramer in brain lipid raft fractions and its changes in spatial learning. J. Neurochemsitry 90:609-20 (2004).
Pascale A., Alkon D.L, and Grimaldi M. Translocation of protein kinase C-ßII from cytosol to membrane-associated Receptor for Activated C Kinase 1 in type I astrocytes requires intact actin cytoskeleton.Glia, 42(6):169-182 (2004).
Watson W.D., Facchina S.L., Grimaldi M., Verma A. SERCA inhibitors identify a novel calcium pool in the central nervous system. Journal of Neurochemistry 87:30-43 (2003).
Grimaldi M. et al. Native TRPC activation mediates novel calcium oscillation but not capacitative calcium entry in astrocytes. The Journal of Neuroscience 23(11):4737-4745 (2003).
Haak L.L., Grimaldi M., Smaili S., Heng P., J.T. Russell. Mitochondria in signaling microdomains: regulation of calcium wave initiation and signal transduction in oligodendrocyte precursor cells. J. Neurochemistry 80(3):405-415 (2002).
Hamelink C., Hyeon-Woo L., Hahm S., Grimaldi M., Eiden L. The neuropeptide PACAP activates a unique combinatorial signal transduction pathway targeting the VIP gene. The Journal of Neuroscience 22(13): 5310-5320 (2002).
Hampson A.J. and Grimaldi M. Glutamate toxicity studies unmask a putative 12-HETE receptor in cortical neurons. The Journal of Neuroscience 22(1):257-264 (2002).
Hampson A. and Grimaldi M. Cannabinoids and elevated cAMP protect against glutamate neurotoxicity. European J. Neuroscience 13(8):1229-1236 (2001).
Grimaldi M. et al. Mobilization of calcium from intracellular stores, potentiation of neurotransmitter induced calcium transients and capacitative calcium entry by 4-aminopyridine. The Journal of Neuroscience 21(9):3135-3143 (2001).
Haak L.L., Grimaldi M., J.T. Russell. Mitochondria in myelinating cells: Calcium signaling in oligodendrocyte precursor cells. Cell Calcium 28(5&6):1-10 (2000).
D’agata V., Grimaldi M., Pascale A., Cavallaro S. Regional and cellular expression of Parkin in the rat cerebral cortex. European Journal of Neuroscience 12:3583-3588 (2000).
Hampson A.J., Grimaldi M., Axlerod J., Wink D. Neuroprotective antioxidants from marijuana. In Reactive oxygen species: from radiation to molecular biology and its implications”, a Festschrift to the work of Daniel Gilbert. Annals of New York Academy of Science Vol. 899 (2000).
Grimaldi M. et al. Prevention of ß-amyloid-induced neuronal death by inhibition of the ubiquitin-proteasome pathway. The Journal of Neurochemistry 75:1258-1263 (2000).
Grimaldi M. et al. PACAP/VIP receptors expression and function in cortical neurons and Type I astrocytes. Annals of New York Academy of Science 921:312-316 (2000).
Grimaldi M. et al. cAMP-induced cytoskeleton rearrangement increases calcium transients through the enhancement of capacitative calcium entry. The Journal of Biological Chemistry. 274:33557-33564 (1999).
Arcone R., Pagliuca M.G., Chinali A., Grimaldi M., Schettini G., Gast A., Pietropaolo C. Thrombin mutants with altered enzymatic activity have an impaired mitogenic effect on NIH3T3 cells and are inefficient modulators of stellation of rat cortical astrocytes. Biochimica et Biophysica Acta 1451(1):173-186 (1999)
Grimaldi M. et al. Functional and molecular diversity of PACAP/VIP receptors in cortical neurons and type I astrocytes. European Journal of Neuroscience. Vol. 11(8):2767-2772 (1999).
Grimaldi M. et al. Bacterial lipopolysaccharide increases interleukin-6 and prostaglandin release in rat cortical astrocytes: role of antiinflammatory agents. Biochemical Biophysical Research Communications Vol. 250(2):798-804 (1998).
Hampson A.J., Grimaldi M., Axelrod J., Wink D., Cannabidiol and 9-tetrahydrocannabidiol are neuroprotective antioxidants. Proceeding of the National Academy of Science USA 95(14):8268-8273 (1998).
Favit A., Grimaldi M., Nelson T.J., Alkon D.L. Alzheimer’s-specific effect of soluble ß-amyloid on PKCß and PKCα degradation in human fibroblasts. Proceeding of the National Academy of Science USA 95(10):5562-5566 (1998).
Grimaldi M. et al. Somatostatin inhibits interleukin 6 release from rat cortical type I astrocytes, via the inhibition of adenylyl cyclase. Biochemical Biophysical Research Communications 235(1):242-248 (1997).
Florio T., Grimaldi M., Scorziello A., Salmona M., Bugiani M., Tagliavini F., Forloni G. Intracellular calcium rise through L-type calcium channels, as a molecular mechanism for prion protein fragment 106-126-induced astroglial proliferation. Biochemical Biophysical Research Communications 228(2):397-405 (1996).
Ventra C., Meucci O., Grimaldi M., Scorziello A., Porcellini A., Absence of D2s dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2l receptor coupled to native transduction mechanism. Journal of Molecular Endocrinology 14(3):375-389 (1995).
Grimaldi M. et al. Synergistic stimulation of IL-6 release and gene expression by phorbol esters and IL-1ß in rat cortical astrocytes: role of protein kinase C blockade and activation. Journal of Neurochemistry 64:1945-1953 (1995).
Grimaldi M. et al. Regulation of IL-6 production and gene expression by rat cortical astrocytes: role of second messenger systems. Polish J. of Pharmacology 46(4):259 (1994).
Pozzoli G., Costa A., Grimaldi M., Preziosi P., Grossman A., and Navarra P.L. Lypopolysaccaride modulation of eicosanoids and corticotrophin releasing hormone relase from rat hypothalamic explants and astrocyte cultures in vitro: evidence for the involvementof prostaglandin E2 but not F2α, and lack of effect of nerve growth factor. Journal of Endocrinology 140:103-109 (1994).
Meucci O., Scorziello A., Avallone A., Ventra C., Grimaldi M., Berlingieri M.T. Alpha 1A and alpha 1B-adrenergic receptors mediate the effect of norepinephrine on cytosolic calcium levels in rat PC CL3 thyroid cells. Thyrotropin modulation of alpha 1B-linked response via a cAMP/protein kinase A-dependent pathway. Endocrinology 134(1):424-431 (1994).
Ventra C., Grimaldi M., Meucci O., Scorziello A., Apicella A., Filetti E., Marino A. Aniracetam improves behavioural responses and facilitates signal transduction in the rat brain. Journal of Psycopharmacology 8(2):109-117 (1994).
Grimaldi M. et al. Regulation of IL-6 production by cAMP-protein kinase A-pathway in rat astrocytes. Pharmacological Research 30(1):13-24 (1994).
Grimaldi M. et al. Vasoactive Intestinal peptide and forskolin stumulate interleukin 6 production by rat cortical astrocytes in culture via a cAMP-dependent prostaglandins-independent mechanism. Journal of Neurochemistry 63:344-350 (1994).
Scorziello A., Landolfi E., Grimaldi M., Meucci O., Ventra C., Avallone A., Postiglione A. Direct effect of Adenosine on Prolactin secretion at the level of the single rat lactotroph: involvement of pertussin toxin-sensitive and -insensitive transducing mechanism. Journal of Molecular Endocrinology 11:325-334 (1993).
Florio T., Meucci O., Grimaldi M., Ventra C., Cocozza E., Avallone A., Postiglione A., Marino A. Effect of Acetyl-L-Carnitine treatment on brain adenylate cyclase activity in young and aged rats. European Neuropsychopharmacology 3:95-101 (1993).
35. Meucci O., Berlingieri M.T., Fusco A., Scorziello A., Santoro M., Grieco M., Grimaldi M. Norepinephrine and Thyrotropin stimulation of [Ca++]i in PC Cl3 rat thyroid epitelial cell line: effect of transformation by E1A gene of adenovirus and polyomavirus middle-T antigen gene. Life Sciences 52:891-899 (1993).
Ventra C., Florio T., Grimaldi M., Meucci O., Marino A. Modulation by GTP of basal and agonist-stimulated striatal adenylate cyclase activity following chronic blockade of D-1 and D-2 dopamine receptors: involvement of G-proteins in the development of dopamine receptor supersensitivity. Journal of Neurochemistry 59(5):1667-1674 (1992).
Meucci O., Landolfi E., Scorziello A., Grimaldi M., Ventra C., Florio T., Avallone A. Dopamine and Somatostatin inhibition of Prolactin secretion from MMQ pituitary cells: role of adenosine triphosphate-sensitive potassium channels. Endocrinology 131:1942-1947 (1992).
Ventra C., Florio T., Meucci O., Grimaldi M., Scorziello A., Talia S., Postiglione A. Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacology Biochemistry and Behaviour 43:139-151 (1992).
Santangelo F., Grimaldi M., Landolfi E., Ventra C., Belfiore A., Meucci O., Santillo M., Mondola P. Effect of calf thymus protein on prolactin release and second messenger systems in rat pituitary cells. Progress in NeuroEndocrinoImmunology 5(3):172-178 (1992).
Grimaldi M. et al. Interleukin 6 modulation of second messengers systems in anterior pituitary cells. Life Sciences 51:1243-48 (1992).
Meucci O., Grimaldi M., Scorziello A., Govoni S., Bergamaschi S., Yasumoto T. Maitotoxin-induced intracellular calcium rise in PC12: involvement of dihydropiridine-sensitive and omega-conotoxin-sensitive calcium channels and phosphoinositides breakdown. Journal of Neurochemistry 59(2):679-688 (1992).
Grimaldi M. et al. Role of Interleukin-6 in the neuroendocrine system. Acta Neurologica 13:361-367 (1991).
Meucci O., Grimaldi M., Florio T., Landolfi E., Scorziello A., Ventra C., Dihydropyridine modulation of K+-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment. Journal of Neurochemistry 56:805-811 (1991).
Florio T., Landolfi E., Grimaldi M., Meucci O., Scorziello A., Marino A. Interleukin-6 mediates neural-immune interactions: study on prolactin release and intracellular transducing mechanisms. Pharmacological Research 22(Suppl.3):54 (1990).
Grimaldi M. et al. Interleukin 1 beta modulation of TRH-stimulated prolactin secretion and inositol phosphate production. Pharmacological Research, 22:(suppl.1):81-82(1990).
Meucci O., Grimaldi M., Florio T., Landolfi E., Ventra C., Scorziello A., Marino A. Cytosolic calcium rise induced by maitotoxin in PC12 cells: effect of omega-conotoxin (GVIA), Pharmacological Research, 22:(suppl.1):75-76(1990).
Meucci O., Grimaldi M., Landolfi E., Scorziello A., Marino A. How maitotoxin increases cytosolic calcium levels? Acta Physiologica Hungarica 75:207-208 (1990).
Marino A., Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C. Fipexide Improvement Of Cognitive Functions In Rat – Behavioural And Neurochemical Studies. Pharmacological Research 22: (2) 179-187 (1990).
Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C., Marino A. Interleukin 1 modulation of anterior pituitary function: effects on prolactin release and post-receptor transducing mechanisms. Annals of New York Academy of Sciences 594: 489-491 (1990).
Florio T., Meucci O., Landolfi E., Grimaldi M., Scala G., Leong D.A., Marino A., Interleukin 1ß modulation of prolactin secretion from rat anterior pituitary cells: involvement of adenylate cyclase activity and calcium mobilization. Endocrinology 162:1435-1441 (1990).
Landolfi E., Meucci O., Florio T., Grimaldi M., Ventra C. and Marino A., Adenosine and its analogue N6- phenylisopropyladenosine (PIA) modulate anterior pituitary adenylate cyclase activity and prolactin secretion. Journal of Molecular Endocrinology, 5:69-76 (1990).
Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C., Scorziello A., Marino A. IL-1 modulation of anterior pituitary function: effect on hormone release and second messenger systems, Pharmacological Research, 21 (Suppl.1):35-36 (1989).
Landolfi E., Meucci O., Florio T., Grimaldi M., Marino A. Anterior pituitary adenosine receptors, coupled to adenylate cyclase, modulate prolactin release", Pharmacological Research, 21 (Suppl 1):5-6 (1989).
Marino A., Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C. Fipexide improvement of cognitive functions in rat: behavioral and neurochemical studies Pharmacological Research 22 (Suppl.2):179-187 (1989).
Landolfi E., Grimaldi M., Meucci O., Postiglione A., Florio T., Ventra C. Interleukin 1ß inhibition of TRH-stimulated prolactin secretion and phoshoinositide turnover. Biochemical Biophysical Research Communications Vol. 165, 1, pg 496-505 (1989).
Florio T., Meucci O., Landolfi E., Grimaldi M., Ventra C., Marino A. Somatostatin inhibition of adenylate cyclase activity in different brain areas. Brain Research 492:65-71 (1989).
Meucci O., Grimaldi M., Florio T., Landolfi E., Scorziello A., Ventra C., Marino A. Dihydropyridine inhibition of K+ and maitotoxin stimulated calcium fluxes in PC12 cells: effect of pertussis toxin, Pharmacological Research, 21 (Suppl.1):1-2 (1989).
Meucci O., Florio T., Grimaldi M., Landolfi E., Magri G. Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels. Pharmacological Research Communications, 20 (12): 1083-1084 (1988).
Landolfi E., Florio T., Meucci O., Grimaldi M., Magri G., Leong D.A. Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay, Pharmacological Research Communications, 20 (12): 1075-1076 (1988).
Florio T., Magri G., Landolfi E., Meucci O., Grimaldi M., Marino A., Depletion of brain somatostatin (SRIF) by cysteamine (CSH) induces impairment of cognitive functions in rat: reversal by exogenous administration of SRIF or its analogue SMS 201-995, Pharmacological Research Communications 20 (3):241-242 (1988).
Florio T., Meucci O., Scala G., Landolfi E., Grimaldi M. Effect of IL-1ß on transducing mechanisms in 235-1 clonal pituitary cells. Part 1: modulation of adenylate cyclase activity. Biochemical Biophysical Research Communications 155: 1089-1096 (1988).
Meucci O., Florio T., Scala G., Landolfi E., Grimaldi M. Effect of IL-1ß on transducing mechanisms in 235-1 clonal pituitary cells. Part II: modulation of calcium fluxes. Biochemical Biophysical Research Communications 155: 1097-1104 (1988).
Meucci O., Florio T., Grimaldi M., Landolfi E., Magri G., Yasumoto T. Pertussis Toxin pretreatment abolishes dihydropyridine inhibition of calcium flux in the 235-1 pituitary cell line. Biochemical Biophysical Research Communications Vol. 151(1):361-369 (1988).
Florio T., Magri G., Grimaldi M., Meucci O., Landolfi E., Marino A. Somatostatin and SMS 201-995 reversal of the impairment of cognitive functions induced by cysteamine depletion of brain somatostatin. European Journal of Pharmacology, 151: 399-407, (1988).