Braunewell, K-H, and A.J. Klein-Szanto (2008) Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+-sensor proteins. Cell & Tissue Research, in press. DOI: 10.1007/s00441-008-0716-3.
Braunewell, K.-H., Brackmann, M., and Hoffmann, A. (2006) VILIP-1, a novel regulator of the guanylate cyclase transduction system in neurons, CBP, 1, 3-7. (PDF file)
Braunewell, K.-H., Brackmann, M., and Hoffmann, A. (2006) VILIP-1, a novel regulator of the guanylate cyclase transduction system in neurons, CBP, 1, 3-7.
Braunewell, K.-H. (2005) The dark side of Ca2+ signaling by neuronal Ca2+- sensor proteins: from Alzheimer`s disease to cancer. Trends in Pharmacological Sciences, 26:345-351.
Blandini, F., Braunewell, K.-H., Manahan-Vaughan, D., Orzi, F., and Sarti, P. (2004) Neurodegeneration and energy metabolism: from chemistry and clinics. Cell death and differentiation, 11, 479-484.
Braunewell, K.-H. and Manahan-Vaughan, D. (2001) Long-term depression - a cellular basis for learning? Rev. Neurosci., 12, 121-140.
Braunewell, K.-H. and Gundelfinger, E.D. (1999) Intracellular neuronal calcium sensor (NCS) proteins - a family of EF-hand calcium-binding proteins in search for function. Cell Tissue Res., 299, 1-12.
Decker, J., Wojtowicz, A, Heinemann, U. and K-H Braunewell (2008) C-type natriuretic peptide modulates pre- and postsynaptic properties in hippocampal area CA1 in vitro. BBRC, in press.
Zhao C, Anand R, Braunewell KH. (2008) Nicotine induced calcium-myristoyl switch of neuronal calcium sensor VILIP-1 in hippocampal neurons - a possible cross talk mechanism for nicotinic receptors" Cell. Mol. Neurobiol. DOI: 10.1007/s10571-008-9320-z.
Gierke P, Zhao C, Bernstein HG, Noack C, Anand R, Heinemann U, Braunewell KH. (2008) Implication of neuronal Ca(2+)-sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia. Neurobiol Dis. 32:162-175.
Zhao, C. and Braunewell, K.-H. (2008) Expression of the neuronal calcium sensor VILIP-1 in the rat hippocampus" Neuroscience, 53:1202-1212.
Fu, J., Fong, K., Bellacosa, A., Ross, E., Apostolou, S., Bassi, D. E., Jin, F., Zhang, J., Cairns, P., Ibañez de Caceres, I., Braunewell, KH and A. J. Klein-Szanto (2008) VILIP-1-Downregulation in Non-Small Cell Lung Carcinomas: Mechanisms and Prediction of Survival. PlosOne, 3:e1698
Dai, F., Zhang, Y., Kang, Y., Gaisano1, H.Y., Braunewell, KH, Chan, C., and Wheeler, MB (2006) A Member of the Neuronal Ca2+-Sensor Protein Family Visinin-like-protein-1 (VILIP-1) is Expressed in Pancreatic ß-cells and Regulates Insulin Secretion and Biosynthesis. J Biol Chem. 281:21942-21953.
Wickborn, C, Klein-Szanto, A., Schlag, PM., and Braunewell, K.-H. (2006) Correlation of protein expression of the putative metastasis suppressor gene VILIP-1 with proliferation in human normal esophagus and tumors. Molecular carcinogenesis, 45:572-81.
Ren, X.-Q., Cheng, S.-B., Treuil, M. W., Mukherjee, J., Rao, J., Braunewell, K.H., Lindstrom, J. M. and Anand, R. (2005) Structural Determinants of a4ß2 Nicotinic Acetylcholine Receptor Trafficking J. Neurosci. 25:6676-6686.
Brackmann, M., Anand, R. and Braunewell, K.-H. (2005) Neuronal calcium sensor (NCS) protein VILIP-1 affects cGMP signalling of guanylyl cyclase B by regulating clathrin-dependent receptor recycling in hippocampal neurons. J. Cell Sci. 118:2495-2505.
Manahan-Vaughan, D. and Braunewell, K.-H. (2005) The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity. Cereb Cortex, 15:1703-1713.
Gonzalez Guerrico, A.M., Jaffer, Z.M., Page, R.E., Braunewell, K.-H., Chernoff, J. and Klein-Szanto, A.J.P. (2005). Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene, 24, 2307-2316.
Brackmann, M., Zhao, C., Schmieden, V. and Braunewell, K.-H. (2004) Expression of the inhibitory GlyR in hippocampal neurons in culture. Biochem Biophys Res Commun. 324:1137-1142.
Gierke, P., Zhao, C., Linke, B., Brackmann, M., Heinemann, U. and Braunewell, K.-H. (2004) Expression analysis of members of the neuronal calcium sensor protein family: combining bioinformatics and Western blot analysis. Biochem Biophys Res Commun. 323:38-43.
Brackmann, M., Zhao, C., Kuhl, D. Manahan-Vaughan., D., and Braunewell, K.-H. (2004) MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3.1/arc in the hippocampus in vivo. Biochem Biophys Res Commun. 322:1073-1079.
Spilker, C. and Braunewell, K.-H. (2003). The calcium-myristoyl switch of neuronal calcium sensor (NCS) proteins: same biochemical principle but different calcium-dependent localization of VILIP-3 and -1 in hippocampal neurons. Mol Cell Neurosci., 24, 766-778.
Pribanic, S., Gisler, S., Bacic, D., Kocher, O., Braunewell, K.-H., Nakadai, T., Murer, H., and Biber, J. (2003) Expression of visinin-like protein 3 in mouse kidney. Nephron - Physiology, 95, 76-82.
Mahloogi, H., Gonzalez-Guerrico, A.M., De Cicco, R.L., Bassi, D. E., Goodrow, T., Braunewell, K. H. and A. J.P. Klein-Szanto (2003) Graduate decrease of VILIP-1 Expression during mouse skin tumor progression and its role in regulating tumor cell invasive behavior. Cancer Res, 63, 4997-5004.
Braunewell, K.-H. Brackmann, M., and Manahan-Vaughan, D. (2003) Group I mGluRs regulate the expression of the intracellular neuronal calcium sensor protein VILIP-1 in vitro and in vivo: possible implications for mGluR-dependent hippocampal plasticity? Neuropharmacology, 44, 707-715.
Bernstein H-G, Becker A, Keilhoff, G., Gorcyca, WA, Braunewell, K-H and Grecksch G. (2003) Ketamine induced changes of the expression of neuronal calcium sensor proteins VILIP-1, -3 and hippocalcin in a partial schizophrenia model in rats. Neuroscience Letters, 339, 95-98.
Spilker, C., Gundelfinger, E. D. and Braunewell, K.-H. (2002b) Different properties of the intracellular neuronal Calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function. BBA-proteins and proteomics. 1600, 118-127.
Lin, L., Jeanclos, E.M., Treuil, M., Braunewell, K.H., Gundelfinger, E.D. and R. Anand (2002b) The Calcium Sensor Protein Visinin-like Protein-1 Modulates the Surface Expression and Agonist-Sensitivity of the 4ß2 Nicotinic Acetylcholine Receptor. J. Biol. Chem. 277, 41872-41878.
Spilker, C., Dresbach, T. and Braunewell, K.-H. (2002a) Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons. J. Neurosci. 22, 7331-7339.
Lin, L., Braunewell, K.H., Gundelfinger, E.D. and R. Anand (2002a) Functional Analysis of Calcium-Binding EF-Hand Motifs of Visinin-like Protein-1. Biochem Biophys Res Commun. 296, 827-832.
Bernstein, H.-G., Braunewell, K.-H., Spilker, C., Danos, P., Baumann, B., Diekmann S., Gundelfinger, E.D. and Bogerts, B. (2002) Hippocampal expression of the calcium sensor protein VILIP-1 in schizophrenia. Neuroreport, 23, 393-396.
Bernstein H.-G., Krell D., Braunewell K.-H., Baumann B., Gundelfinger E.D., Diekmann S., Danos P., Bogerts B. (2001) Increased number of nitric oxide synthase immunoreactive Purkinje cells and dentate nucleus neurons in schizophrenia. J Neurocytol., 8, 661-670.
Schnurra, I., Riederer, P., Bernstein, H.-G. and Braunewell, K.-H. (2001) The neuronal calcium sensor (NCS) protein VILIP-1 is associated with amyloid plaques and extracellular tangles and promotes cell death and tau-phosphorylation in vitro: a link between calcium sensors and Alzheimer`s disease? Neurobiology of disease, Neurobiol Dis. 8, 900-909.
Braunewell, K.-H., Brackmann, M., Schaupp, M., Spilker, C. Anand, R., and Gundelfinger, E. D. (2001) Intracellular neuronal calcium sensor (NCS) protein VILIP-1 modulates cGMP signalling pathways in transfected neural cells and cerebellar granule neurones. J. Neurochem. 78, 1277-1286.
Braunewell, K.-H., Riederer, P., Spilker, C., Gundelfinger, E.D., Bogerts, B. and Bernstein, H.-G. (2001) Abnormal Localization of two Neuronal Calcium Sensor Proteins, Visinin-Like Proteins (VILIPs) -1 and -3, in Neocortical Brain Areas of Alzheimer Disease Patients. Dement Geriatr Cogn Disord. 12, 110-116.
Budde T., Sieg, F., Braunewell, K.-H., Gundelfinger, E. D., and H.-C. Pape (2000) Calcium-induced calcium release mediates the relay mode of thalamocortical cells. Neuron, 26, 423-432.
Probstmeier, R., Braunewell, K.-H. and P. Pesheva (2000) Involvement of chondroitin sulfates on brain-derived tenascin-R in carbohydrate-dependent interactions with fibronectin and tenascin-C. J. Neurosci. Res. 863, 42-51.
Spilker, C., K. Richter, K.-H. Smalla, D. Manahan-Vaughan, Gundelfinger, E.D. and Braunewell, K.-H. (2000) The neuronal EF-hand calcium-binding protein VILIP-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association. Neurosci. 96: 121-129.
Bernstein H-G, Baumann B, Danos P, Diekmann S, Bogerts B, Gundelfinger ED, Braunewell K-H (1999) Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain. J Neurocytol., 28, 655-662.
Manahan-Vaughan, D., Braunewell, K.-H. (1999) Novelty Acquisition is associated with induction of hippocampal long-term depression. Proc. Natl. Acad. Sci. USA, 96, 8739-8744.
Manahan-Vaughan, D., Braunewell, K.-H. and Reymann, K.G. (1998) Subtype-specific involvement of metabotropic glutamate receptors in two forms of long-term potentiation in the dentate gyrus of freely moving rats. Neuroscience, 86, 709-721.
Braunewell, K.-H. and Gundelfinger, E.D. (1997) Low level expression of calcium-sensor protein VILIP induces cAMP-dependent differentiation in rat C6 glioma cells. Neurosci. Lett., 234, 139-142.
Spilker, C., Gundelfinger, E.D. and Braunewell, K.-H. (1997) Calcium- and myristoylation-dependent subcellular localization of the neuronal calcium-binding protein VILIP in transfected PC12 cells. Neurosci. Lett., 225, 126-128.
Braunewell, K.-H., Spilker, C., Behnisch T. and Gundelfinger, E.D. (1997) The neuronal calcium-sensor protein VILIP modulates cAMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity. J. Neurochem., 68, 2129-2139.
Boekhoff, I., Braunewell, K.-H., Adreini, I., Breer, H. and Gundelfinger, E. D. (1997) The calcium-binding protein VILIP in olfactory neurons: regulation of second messenger signalling. Eur. J. Cell Biol.,72, 151-158.
Lenz, S. E., Braunewell, K.-H., Weise, C., Nedlina-Chittka, A. and Gundelfinger, E. D. (1996) The neuronal EF-hand calcium-binding protein VILIP: interaction with cell membrane and actin-based cytoskeleton. Biochem. Biophys. Res. Commun., 42, 145-158.
Lochter, A., Taylor, J., Braunewell, K.-H., Holm, J., and Schachner, M. (1995) Control of neuronal morphology in vitro: Interplay between adhesive substrate forces and molecular instruction. J. Neurosci. Res. 42, 145-158.
Braunewell, K.-H., Pesheva, P., McCarthy, J. P., Furcht, L. T., Schmitz, B. and Schachner, M. (1995) Functional involvement of sciatic nerve-derived versican- and decorin-like molecules and other chondroitin sulfate proteoglycans in cell adhesion and neurite outgrowth. Eur. J. Neurosci, 7, 805-814.
Braunewell, K.-H., Martini, R., LeBaron, R., Kresse, H., Faissner, A., Schmitz, B. and Schachner, M. (1995) Upregulation of a chondroitin sulfate epitope during regeneration of mouse sciatic nerve: evidence that the immunoreactive molecules are related to the chondroitin sulfate proteoglycans decorin and versican. Eur. J. Neurosci., 7, 792-804.
Brackmann, M., Hoffmann, A. and Braunewell, K.-H. (2006) Structure, function and expression of members of the VILIP (visinin-like protein) subfamily of neuronal Ca2+ sensor proteins. In: "Neuronal calcium sensor proteins", Molecular Anatomy and Physiology of Proteins, (Ed. V. Uversky, Co-Eds. K.-W. Koch, P. Phillipov) Nova Science Publisher.
Braunewell, K.-H., C. Reissner and Gundelfinger, E.D. (2000) Visinin-like proteins (VILIPs) - Emerging role in cross-talk between cellular signaling pathways. In: Calcium: the molecular basis of calcium action in biology and medicine (Ed. R. Pochet, Co-Eds. R. Donato, J. Haiech, C. Heizmann, V. Gerke) Kluwer Academic Publishers.
Braunewell, K.-H. und Gundelfinger, E.D. (1997) Neurochemie. In: Methoden der Hirnforschung (Kischka, U., Wallesch, C.-W. und Wolf, G., Hrsg.) Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford.
Gundelfinger, E.D. und Braunewell, K.-H. (1997) Molekularbiologie. In: Methoden der Hirnforschung (Kischka, U., Wallesch, C.-W. und Wolf, G., Hrsg.) Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford.
Braunewell, K.-H. und Braun, K. (1997) Zellkulturen. In: Methoden der Hirnforschung (Kischka, U., Wallesch, C.-W. und Wolf, G., Hrsg.) Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford.
Braunewell, K.-H., Lenz, S.E. and Gundelfinger, E.D. (1996) VILIP (Visinin-like-Protein). in: Guidebook to Calcium Binding-Proteins. Oxford University Press, Oxford, pp. 107-109.