Radiation Treatment

Southern Research offers state-of-the-art irradiation capabilities to assist clients with in vivo anticancer efficacy testing and in vitro survival assays. Radiation treatment is commonly used as a singular treatment approach or as an adjuvant therapy in combination with surgery or chemotherapy. A primary focus among researchers is the identification of compounds that will selectively sensitize cancerous tissues to radiation therapy as well as the investigation of compounds that have a protective effect on healthy tissues exposed to radiation during treatment.

Equipment/Capabilities

Our irradiation facility is located within our in vivo laboratories where we conduct combination xenograft studies with human tumor models. As an advanced imaging technology available to our clients, we offer a Precision X-ray Inc., X-RAD 320 X-ray irradiator that is fully calibrated. This equipment is available to our clients for both in vivo radiation studies as well as in vitro survival assays using the clonogenic survival assay.

Our highly experienced scientists have completed and published a radiosensitization study with clofarabine in the DLD-1 colon xenograft model. Moreover, Southern Research has evaluated the radiosensitizing potential of clofarabine in the following models:

• NCI-H460 lung
• SR475HN head and neck
• SF-295 glioblastoma
• DU-145 prostate
• PANC-1 pancreatic
• HCT-116 colon tumor

Additionally, we have established a radiation-induced mucositis model in rats. All of our xenograft models are available for radiation studies.