ADME/PK

Pharmacokinetics is the study of the rate of change of drug/drug metabolite concentrations in the body. PK data is a requirement in the preclinical evaluation of compounds and provides pertinent information for the design of required toxicology studies. Because time is a critical factor in compound evaluation and drug development, Southern Research has developed the PK Kwik program to rapidly obtain this important data. PK Kwik provides our clients with accurate in vivo PK data in days rather than weeks for most small molecule compounds. Typical PK parameters generated from these studies include: Cmax, Tmax, AUC, drug clearance, terminal elimination half-life, and volume of distribution. By having both IV and PO routes of administration, compound bioavailability may also be determined. This process provides our clients the ability to make early decisions regarding their compound in the development process, saving both time and money.