Southern Research has purchased a 100,000 compound library from ChemBridge Corporation for use in its HTS program. The library was pre-filtered using a number of drug-likeness parameters including molecular weight <500, <5 hydrogen bond donors, and <10 rotable bonds. Over 28 reactive groups such as carbodiimides, diazonium salts, peroxides, and diazines were also removed. The final result is 100,000 compounds with drug-like properties that meet a number of criteria including the Lipinski rules. Smaller sets of 3,000 and 10,000 compounds have been made that represent the chemical diversity of this library. Access to this library is available with a contracted high-throughput screening service.
In addition to this commercially purchased library, Southern Research has its own proprietary compound library from the results of over 30 year of medicinal chemistry at the Institute. As a collection of ~20,000 compounds this is a unique resource not available commercially. Various unique smaller compound collections are also available on-site, including some natural product collections. These libraries are available pending agreement of the suppliers to have them used in a particular assay.
High-Throughput Screening
HTS Informatics
HTS Equipment
HTS Publications
HTS Virtual Poster Session
Chemical Repository