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Southern Research has a multi-million dollar investment in its HTS center. The space and equipment are described in the HTS Equipment page. The staff is experienced in moving bench top assays to the robotics platform and has run target and cell-based screens. The center has five, large successful HTS screening programs with NIH – Mycobacterium Tuberculosis drug screening which has been recently supplemented with funding for four biodefense related targets, an in vitro antiviral screening program for SARS CoV and influenza, high-throughput screening for neurodegenerative diseases, screening for HIV targets, and the NIH Roadmap molecular libraries screening network.
The Mtb screening project is designed to develop and implement biochemical, target-specific Mtb drug screening assays in an HTS format. Investigators with novel M. tuberculosis biochemical targets are encouraged to submit proposed assays to NIAID for inclusion in the M. tuberculosis HTS target panel. Please contact Dr. Barbara Laughon (NIAID: BLaughon@niaid.nih.gov) or Lucile White (Southern Research: white@southernresearch.org) for more information. A summary of the program is available at http://www.taacf.org/SRI-HTS.htm.
To encourage the use of HTS for neurodegeneration research and drug discovery, NINDS awarded a contract to Southern Research in September 2002. Southern Research provides to the research community a resource for testing assays against a large, diverse collection of compounds. Assay proposals from scientists in the field are solicited by NINDS through notices published in the NIH Guide for Grants and Contracts.
The Molecular Libraries Screening Centers Network (MLSCN), a component of NIH Roadmap, is a national resource capable of providing automated high-throughput screening (HTS) facilities, diverse compound libraries, and HTS for the identification of small molecules (compounds) that are active in diverse biological assays, as well as synthetic chemistry to improve the biological utility of these molecules as bioactive probes for in vitro, and potentially in vivo, studies of normal and abnormal physiology of cells, organs, model systems, and/or organisms. The ultimate goal of this program is to use as screens a variety of innovative biological, biophysical and cell-based assays for biological targets or processes for which there are limited selective and potent small molecule modulators available to the public. Read Program Announcement.
The MLSCN is soliciting applications from investigators who have developed innovative assays and are interested in having their assay used in the MLSCN to screen a large number of compounds. In 2005 Southern Research was named as one of nine national screening centers.
High-Throughput Screening Center
HTS Informatics
HTS Equipment
HTS Publications
HTS Virtual Poster Session
Chemical Repository