Infectious Disease Research
Emerging Pathogens
Animal Studies Program
In vivo Services
- Vaccine efficacy/safety testing
- Drug efficacy/safety testing
- Animal model development
- In vivo pathogenesis studies
- Production of hyper-immune sera
- Custom in vivo assays
- GLP studies
- Consultation
Current Capabilities
Animal model development and validation
- SARS-CoV (rodent, ferret, nonhuman primate)
- Pox viruses (rodent)
- Highly pathogenic avian influenza viruses (rodent, ferret)
- Bacillus anthracis (rodent)
Vaccine efficacy studies
- SARS-CoV
- Highly pathogenic avian influenza viruses
- Bacillus anthracis
Drug efficacy studies
- Anthrax lethal toxin (rats)
- Cowpox (mice)
Available Animal Models:
- SARS-CoV (rodent, ferret, nonhuman primate)
- Pox viruses (rodent)
- Anthrax lethal toxin (rat)
- Bacillus anthracis (rabbit, rodent)**
- Highly pathogenic avian influenza viruses (rodent, ferret)*
* available in early 2005
** available in Fall 2005
Model Development/Validation
A. Available Animals
Rodent species
- Mice
- Rats
- Cotton rats
- Hamsters
- Gerbils
- Guinea pigs
Non-rodent species
- Ferrets
- Rabbits
- New World Monkeys
B. Available Pathogens
Viral Pathogens
- SARS-CoV
- Pox viruses
- Highly Pathogenic Avian Influenza virus
- West Nile Virus
- Dengue
- Rift Valley Fever
- Venezuelan equine encephalitis
- Eastern equine encephalitis
- Western equine encephalitis
- Hantaviruses
- Bunyaviruses
Bacterial Pathogens
- Mycobacterium tuberculosis
- Bacillus anthracis
- Yersinia pestis
- Francisella tularensis
