Cancer

In Vivo

Southern Research is a recognized pioneer in anti-cancer drug development drawing on the unique expertise gained from a relationship with the National Cancer Institute since 1957. We have screened thousands of potential anti-cancer compounds, including most of the FDA approved drugs, and developed a proprietary database that includes efficacy information on most clinically active agents. Our unparalleled experience allows us to optimally design studies that provide critical preclinical efficacy data for your regulatory application. We provide responsive and experienced study directors with years of experience performing preclinical efficacy studies in immune-compromised and immune competent mice. We can help you move your product by conducting the following evaluations:

• Antitumor efficacy models
• Early vs. late stage disease comparisons
• Evaluations to maximize compound effectiveness
• Establish maximum tolerated dose
• Determine schedule dependency
• Compare formulations and routes of administration
• Determine minimum effective dosage
• Establishing combination chemotherapy effectiveness with clinically useful agents
• Cross resistance profiles
• Spectrum of activity analyses

Tumor model development and existing models (>100 available) including:

• Xenografts in athymic nude or SCID mice (>80 available, both adult and pediatric)
• CNS
• Lung
• Kidney
• Hepatic
• Gastric
• Pancreatic
• Melanoma
• Leukemia/Lymphoma
• Colon
• Prostate
• Head and Neck
• Breast
• Ovarian
• Orthotopic xenograft or syngeneic mouse model development and established models
• Breast
• Kidney
• Lung
• CNS
• Prostate
• Syngeneic mouse models
• Melanoma
• Lung
• Colon
• Leukemia (sensitive and corresponding drug-resistant models)
• Breast
• Pancreatic
• Kidney
• Metastasis models
• Xenograft
• Syngeneic
• Specialized models
• Angiogenesis
• Arthritis
• Tolerance studies
• Chemoprevention
• Gene therapy
• In vivo immunology
• Related services
• In vitro cytotoxicity screening
• I.V. (internal and external pump) S.C., I.P infusions in mice
• Tissue sample collection for PK and PD analysis
• Working with H3 and C14 labeled compounds
• Pathology
• Histopathology
• Immunology

Our staff has extensive experience in a wide variety of specialized techniques and delivery methods to optimally test your compounds. Our facilities are AAALAC-accredited and can house 18,000 mice.