Cancer

In Vitro

Since the 1970s, Southern Research has provided cell biology and other in vitro pharmacology-based services to the pharmaceutical industry and the National Cancer Institute.

The services we provide are instrumental in drug development and can provide insight to designing in vivo efficacy studies. We are highly flexible in assay design and work closely with our clients to develop an experimental plan. All work is carried out under well-defined SOPs by highly qualified technicians in state-of-the art laboratories.

Most studies can be conducted under GLP compliance if required. We take great pride in the quality of services offered that meet the highest scientific standards and strive to keep costs low and complete studies in a timely manner.

Extensive panel of over 200 human tumor lines including drug resistance models

Custom assay and method development

Quantitative dose-response analysis of growth inhibitory activity or cytotoxicity

Combination and sequencing studies with isobologram analysis

Cell cycle analysis

Apoptosis measurements

Angiogenesis assays

Mechanism of action

Signal transduction studies

Biomarker analysis

Flow cytometry

Gene and protein expression

Enzyme and receptor binding assays

Imaging and cellular localization

in vitro myelotoxicity assessment

Normal cell models including primary cultures

Immunohistochemistry and related methods

Hollow fiber screening assay