Angiogenesis
The Southern Research Angiogenesis Program offers an integrated series of in vitro and in vivo assays to screen and evaluate compounds and biological agents affecting the angiogenic process.
Since an imbalance in angiogenesis contributes to numerous human diseases, the modulation of angiogenesis as a therapeutic strategy has become a rapidly expanding field for drug discovery and development.
In vitro assays
- Endothelial cell proliferation
- Cell migration / invasion
- Endothelial tube formation
- Endothelial cell apoptosis
- Assays using tumor and endothelial cell co-cultures
- Cell-based angiogenesis High Throughput Screening (HTS)
In vivo assays
- Matrigel Plug assay in mice with quantitative analysis of microvessel density
- Chick Chorioallantoic Membrane (CAM) assay with quantitative analysis of blood vessel density
- Xenograft CAM assay with quantitative analysis of blood vessels on CAM and within xenograft tumors
- Xenograft mouse study with analysis of angiogenic effect, including tumor microvessel density, and levels of angiogenic growth factors in blood serum and tumor samples
- A new xenograft mouse model with regulated tumor angiogenesis and inducible metastatic phenotype, used in preclinical efficacy studies to test potential anti-cancer drugs and to evaluate new treatment modifications
Southern Research works closely with its clients and is flexible in assay and experiment design based on the objectives of each study.
2005 AACR Poster Presentations
Download our poster presentations in Adobe PDF format.
